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Novel genetically engineered mouse models using the Cre- loxP or the Flp- FRT systems have generated useful reagents to manipulate the mouse genome in a temporally-regulated and tissue-specific manner.
MIT researchers' new platform detects and extracts rare circulating tumor cells from live mouse models using a combination of laser excitation and a microfluidic chip.
We also conducted a series of in vivo experiments with xenograft mouse models using both amelanotic (A375, UMSCC1-Luc) and melanotic B16F10-Lucc) celinesnes.
Although there are several publications that describe IAE-like mouse models using LPS administration in addition to influenza virus infection29,30, the routes, doses, and timings of LPS administration differ between these studies.
We developed SCA8 transgenic mouse models using the endogenous human promoter on a BAC clone to express the CTG with either a normal or expanded repeat tract (Fig. 1a).
Smith B.R., Cheng Z., De A., Rosenberg J., Gambhir S.S. Dynamic Visualization of RGD-Quantum Dot Binding to Tumor Neovasculature and Extravasation in Multiple Living Mouse Models Using Intravital Microscopy.
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The majority of mouse models used in research involve knock-in (reporters or recombinases) or gene replacement (e.g., conditional knockout alleles containing exons flanked by LoxP sites).
The two mouse models used in this study represented this second type of malignancy with the extreme aggressiveness in which the survival times, if treated unsuccessfully, are between 13 and 15 days.
Studies have shown altered cerebral blood flow in DMD, but the mouse models used in these studies did not have mutations that were predicted to affect Dp71 of Dp4052.
In February, a study published in PNAS reported that the mouse "models" used extensively to study human inflammatory diseases (in sepsis, burns and trauma) have been totally misleading.
All mouse models used in the study were bred on a C57B6/J background.
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