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Further evidence from AD mouse models shows that a decline in the density of the synaptic marker synaptophysin and in dendritic spine density have also been detected at a time, when only soluble Aβ but no amyloid plaques were present [15] [18].
OA cartilage in both humans and mouse models shows increased expression of HIF-2α.
Despite their independent derivation, lupus nephritis in both MLR/lpr and NZB/W mouse models shows a remarkably efficacious response to sirolimus treatment [ 20- 22].
Diabetes is a typical symptom of FRDA patients, and electron microscopic analysis of the neurons and cardiac muscles in mouse models shows an increase in lipid droplets [ 54], suggesting that there may be changes in lipid metabolism.
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Both mouse models show that TLX1 can induce T-ALL.
Since all circadian gene-mutant mouse models show increased sensitivity to γ-radiation, we conclude that the molecular clock functions in tumor suppression in vivo.
However, current humanized mouse models show sub-optimal human T cell reconstitution and limited ability to support immunoglobulin class switching by human B cells.
The combination of SS1P with chemotherapy is based on results from in vivo mouse models showing marked synergy between SS1P and chemotherapy [23] [26].
In vivo primary glioblastoma mouse models show efficacy.
Transgenic mouse models show that HER-2 promotes the development of mammary tumours [ 6].
"Mouse models show that if you accelerate mitochondrial degeneration, you get premature aging.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com