Sentence examples for mouse models suggesting from inspiring English sources
Triple (plcABC) and quadruple (plcABCD) mutants have negligible enzyme activity and attenuated virulence in mouse models, suggesting that phospholipase C activity is required for the growth of mycobacteria in vivo [40].
Depletion of Treg using an antibody or genetic deletion also greatly diminished lung tumorigenesis in other K-Ras driven mouse models, suggesting a new strategy that might have utility for lung cancers characterized by mutations in K-Ras.
A number of recent studies however have now shown motor neuron axon guidance and elongation is unperturbed in SMA mouse models, suggesting that decreased levels of ß-actin in motor neuron growth cones likely does not hinder axon guidance or elongation [17] [19].
We also consider evidence from mouse models suggesting that SMN has its predominant action on the neuromuscular system in early postnatal life, during a discrete phase of development.
miR148b expression in breast cancer cells impairs lung colonization in mouse models, suggesting a role in regulating genes contributing to metastasis.
We found that mean Hx levels remained above baseline in each of the mouse models, suggesting that the study of heme-related pathophysiology in mouse models of infection may not reflect the human condition.
Experimental evidence in mouse models suggests that the degradation of the extracellular matrix by matrix metalloproteinases (MMPs) plays an important role in infarct rupture.
These observations along with experimental evidence in cellular and mouse models suggest that TG2 can contribute to the abnormal aggregation of disease causing proteins and consequently to neuronal damage.
However, chronic gastrointestinal dysfunction suffered by a subset of patients after surgery as well as studies in HSCR mouse models suggest that aberrant NC segregation and differentiation may be occurring in ganglionated regions of the intestine.
As an example, ciliopathies like BBS are associated with diabetes mellitus and obesity, and mouse models suggest a role for cilia in controlling hyperphagia [25].
Studies on human samples indicate that the cell-of-origin is likely a cone photoreceptor [35, 36] whereas studies in mouse models suggest a horizontal cell [37], or a Müller glia cell [38].
