Sentence examples for most nonsynonymous mutations from inspiring English sources

Because most nonsynonymous mutations are selected against, the vast majority of genes exhibit ratios of nonsynonymous to synonymous substitution that are lower than 1.

On the other hand, πS > πN is expected in the case of real polymorphisms because most nonsynonymous mutations are deleterious and are eliminated by purifying selection (Hughes 1999).

Whereas the 'infinitely many parameters' approach used by Tamuri et al. (2012) led to the conclusion that most nonsynonymous mutations have, panel b shows that most have a selection coefficient between −10 and −2, with the mode situated at −5.

Most nonsynonymous mutations are thought to be deleterious because of their effect on protein sequence and are expected to be removed or kept at low frequency by the action of natural selection.

Since most nonsynonymous mutations are likely to be deleterious, it is expected that levels of population differentiation at these selectively constrained sites should be lower than those at less constrained sites (e.g., 4-fold sites) (Barreiro et al., 2008; Maruki et al, 2012).

ω is generally less than 1 when considering the genome as a whole, reflecting the widely accepted theory that most nonsynonymous mutations have harmful effects on fitness and are therefore removed by purifying selection (Pál et al. 2006; Eyre-Walker and Keightley 2007).

In most cases nonsynonymous mutations were found in the 90th, 94th, and 95th codons of this gene.

This is expected if most segregating nonsynonymous mutations are slightly deleterious, as is suggested by their negative values of Tajima's D (Table 4), because purifying selection is more effective at removing deleterious mutations when Ne is large.

In addition, most of the nonsynonymous mutations that were observed in the genomes of patients are common polymorphisms widely distributed throughout the global mtDNA tree.

It was identified that most of the nonsynonymous mutations have impact on three-dimensional structure of this protein [ 6].

Interestingly, in CRB, one of the most heterozygous strains, nonsynonymous mutations are more frequent in homozygous SNPs than in heterozygous SNPs (24% vs. 22%, respectively; P < 0.0001, χ test of association), suggesting that these mutations could represent important functional adaptations.