Sentence examples for most disruptive mutations from inspiring English sources

The most disruptive mutations occur at the edges of stems.

This finding is potentially interesting because hypopharyngeal carcinoma is the most fatal among HNSCCs, 29) and because p53 disruptive mutations serve as an adverse prognostic factor in HNSCCs.

Since the M10 mutation in brown hyena may have arisen independently of the mutations found in Felidae, we expanded our search for the presence of similarly disruptive mutations to include taxa representative of most other Carnivora families (with the exception of Eupleridae, Mephitidae, and Odobenidae).

Mutation sets predicted to be the most disruptive at the dimerization interface are found to be less specific to the flexible template than sets predicted to be less disruptive.

In particular, mutations in ATRX L1276 and ATRXL1280 had the most disruptive effects, and double mutants (ATRXL1276R/L1280R and ATRXL1276Q/L1280Q) completely abolished the interaction with DAXXDHB (Fig. 2B).

Although disruptive mutations in the mitochondrial DNA (mtDNA) are the most significant hallmark of such tumors, oncocytomas may be envisioned as heterogeneous neoplasms, characterized by multiple nuclear and mitochondrial gene lesions.

Starting Up: Disruption Alyson Shontell says these are the 11 most disruptive start-ups.

The most disruptive children dominated the schools.

Most disruptive was the rise of the drugs trade.

He was the most disruptive defensive player of his era.

"That makes this move potentially the most disruptive change yet".