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Most other mutations they studied introduced a bulged nucleotide.
Somatic evolution is suppressed because only mutations that occur in stem cells are retained, while most other mutations are lost.
Most other mutations observed here have previously been implicated in the biology of mucinous ovarian tumors (KRAS, BRAF, TP53, CDKN2A, PIK3CA, PTEN) [ 14, 15, 18– 20, 38].
Most other mutations are deleterious or lethal, because they either reduce the speed with which an organism produces copies of itself or destroy that ability altogether.
There is no evidence that the corresponding nucleotide change c.388C>T represents a hypermutable position, raising the possibility that most other mutations in the HSD17B10 gene are not observed because they are incompatible with life.
This explanation is consistent with the observation that intracellular COL4A1 for Col4a1 +/S1582P MEFs was predominantly soluble monomers whereas for most other mutations, intracellular COL4A1 had significant contributions of soluble and insoluble heterotrimers (Fig. 5H).
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Unlike most other cancers, mutations and epigenetic changes in HER2, MET and FGFR2 are rarely observed in GC (Asaoka et al, 2011).
Similarity in the topology of genes derived from Sabin 1 and genes derived from Sabin 2 strongly suggests that the recombination occurred before most of the other mutations, probably soon after vaccination.
Most of the other mutations studied have only been observed in low numbers of PD patients and further work is required to assess the contributions these mutations make to the development of disease [ 6].
Most of the other mutations affect the biophysical properties of the Aβ peptide and have a diverse array of effects, but, as indicated in Figure 2 they consistently increase the toxic amyloid potential of the protein, thereby increasing the tendency of Aβ to oligomerize.
Cancers of the prostate, pancreas, breast, ovaries — and most other tumors — carry few mutations.
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