Among the most frequent mutations are those occurring in genes that are activated by interferon and in genes that play a role in regulating immune response.
The most frequent mutations in each dataset were relatively common, validating our approach.
The most frequent mutations affect TERT promoter (60%), associated with an increased telomerase expression.
Even with the 10,000 most frequent mutations in TCGA, only 68% of Broad patients are covered.
b The ten most frequent mutations in TCGA are presented with their coverage of TCGA and Broad patients.
Three of the top 10 most frequent mutations in TCGA are not seen at all in the Broad dataset.
Interestingly, there is a marked difference in the prevalence of the 10 most frequent mutations in TCGA between the two datasets (Fig. 4b).
A panel of 400 hotspots delineated in the TCGA dataset is highlighted for ease of interpretation the 400 most frequent mutations in TCGA cover 55.49% of Broad patients.
Thirty 18- to 24-mer oligonucleotide probes were designed to target the most frequent mutations in three polymorphic loci of Sinorhizobium meliloti and S. medicae.
Lung cancer is the leading cause of cancer related deaths worldwide and mutation activating KRAS is one of the most frequent mutations found in lung adenocarcinoma.
The most frequent mutations among these XDR-TB isolates were katG315 and inhA-15 (for INH), 531, 526 and 516 in rpoB (for RIF), rrs1401 and eis 10 (for KAN) and 94, 90 and 91 in gyrA (for OFX).
