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"The question now is, do these changes plateau after six months, or will longer-duration missions mean there will be even more astronauts experiencing more severe abnormalities?" Dr Kramer said.
There was variability in the onset of severe placental defects, with congenic C57BL/6 Pkd1−/− mice generally exhibiting more severe abnormalities at earlier time points compared with the mixed background.
Liver function abnormalities occurred in patients with intercurrent illnesses and more severe abnormalities were noted in patients with liver cirrhosis.
More severe abnormalities of static posture disrupting spinal alignment and leading to significant disability include camptocormia, antecollis, Pisa syndrome, and scoliosis [ 3, 4].
In mice, heterozygous inactivation of p300 leads to more severe abnormalities in heart, lung, and small intestine formation than inactivation of CBP.
We hypothesized that individuals with diabetes would have more severe abnormalities of mineral metabolism at comparable levels of renal dysfunction than patients without diabetes (lower serum calcium, higher serum phosphate, PTH, and FGF23 levels).
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A sample was considered positive if the diagnosis was ASCUS or a more severe abnormality (ASCUS+).
A critical P-AE was defined as a vital sign or arterial blood gas analysis parameter with more severe abnormality detected (category 2 or worse), as well as other life-threatening events such as airway obstruction, accidental extubation, cardiac arrest, malignant arrhythmias, and others.
Moreover, we observed more-severe abnormalities in the organization of both cortical MTs and F-actin in rigor-KCBP trichomes when compared to the wild-type control.
Such studies may also clarify whether the trends we observed of more severe cartilage abnormalities, BMLs, and osteophytes in males are meaningful.
A similar development could not be observed on the tibial side, indicating that the femoral tunnel has the potential to cause more severe growth abnormalities than the tibial tunnel.
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more extreme abnormalities
more severe flaws
more severe faults
more severe alterations
more severe defects
more severe malformations
more severe disorders
more functional abnormalities
more common abnormalities
more neurological abnormalities
more severe droughts
more severe conditions
more serious abnormalities
more severe injuries
more severe symptoms
more somatosensory abnormalities
more metabolic abnormalities
more complex abnormalities
more Ca2+ abnormalities
more structural abnormalities
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