Sentence examples for more severe defects from inspiring English sources

However, we observed more severe defects using this approach than when using stable transgenic lines expressing dCas9.

The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development.

This neuropeptide signaling pathway operates independently of the TRPV genes, osm-9 and ocr-2, since mutants lacking npr-1 and both TRPV channels had more severe defects in heat avoidance than mutants lacking only npr-1 or both osm-9 and ocr-2.

In support of this hypothesis, we show here that compound Foxc1; Foxc2 homozygotes die earlier and with much more severe defects than single homozygotes alone.

A mutant lacking the periplasmic cytochrome MtrA demonstrated more severe defects.

Similar, but more severe defects were observed in K5-β1 skin (Figure 2A,B,E).

However, the distinct pattern of mutant Tdp1 activity evident in yeast cells, suggests a more severe defect in Tdp1H432N-catalyzed resofution of 3′ phospho-adducts.

zmm mutants show decreased levels of crossovers at both 23 and 33°C, with a more severe defect at 33°C [16].

The lack of episomes in GM15808 suggest that their more severe defect in both NBS1 and MRE11contributes to their failure to support episomal maintenance of EBV.

Notably, a more severe defect was observed in the posterior peak of Hb expression (Figure 6B), that is normally positioned at 80 to 88% of EL [34].

A more severe defect in growth rate was observed for Tnhfq2, which took over fifteen hours to exit lag phase (Fig. 3B).