Sentence examples for more severe malformations from inspiring English sources
Fgfr2 +/P253R mice might show more severe malformations at other anatomical locations or have other tissues or developmental systems more severely affected.
Future studies need much larger sample sizes, preferably with sufficient power to further investigate potential associations with more severe malformations.
Early rupture would lead to more severe malformations (eg, craniofacial and visceral) whereas later rupture would lead to milder forms.
Subjects with more severe malformations demonstrated poorer performance, but this may have been attributable to preoperative factors rather than to implant performance [ 57].
These characteristic alterations were similar in both heterozygous and homozygous embryos, although homozygous embryos presented more severe malformations of the eye (Fig. 3E,G).
More severe malformations included frontonasal and midline defects (supplementary material Fig. S1C,D,G and Fig. S2C,F,J) and brain anomalies including anencephaly, microcephaly and exencephaly (supplementary material Fig. S1C,D,G and Fig. S2C,F,J).
This seems surprising, as combined CL/P is a more severe malformation that might be expected to result in greater global morphologic differences.
There was no association between bicuspid valves and the presence of DORV (X = 0.35, P > 0.5; Supplementary material online, Table S1 ); thus, BAV was not secondary to these more severe outflow malformations.
In fact, regional deletion of Eng caused more severe cerebrovascular malformation per copy than Alk1 with VEGF stimulation.
We observed a slightly more severe gyral malformation intermediate between grades 2 and 3, and mild cerebellar vermis hypoplasia in one patient each.
Convenient home pregnancy tests had not yet been invented and the thalidomide disaster – in which hundreds of children in the UK and many more elsewhere were born with more or less severe malformations after their mothers had taken a morning-sickness drug – was still to come.
