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The individuals with a CAC score > 0 also had higher blood pressure and had more metabolic abnormalities.
People with MetS (three or more metabolic abnormalities) were more likely to have ischemic heart disease and stroke and to be taking hypertension medications.
The individuals with a CAC score > 0 also had higher blood pressure and had more metabolic abnormalities including higher TG and LDL-C concentrations and lower HDL-C concentration.
Altogether, 17.3% had three or more metabolic abnormalities, of these, 60.7% had three, 33.0% had four, and 6.3% had all five. 1 Standardized to the Russian population in 2002 by the following age-strata 20-29, 40-49, 40-49, 50-59, 60+ years.
All the 15 of the 116 (12.9%) patients with altered sensorium manifested one or more metabolic abnormalities [hyponatremia (n = 9); hypokalemia (n = 7); hyperbilirubinemia (n = 3); elevated transaminases (n = 12) elevated blood urea (n = 11); and elevated serum creatinine (n = 3)] or type II respiratory failure and carbon dioxide retention (n = 11).
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Thus 63.8% of normal weight individuals had one or more metabolic abnormality.
It should be noted that the affected women in the family cohort were heavier, more hyperandrogenemic based on nominal testosterone values, and had more prominent metabolic abnormalities than the PCOS women from the case-control cohort, which may be due to the fact that the former were all hyperandrogenemic by definition and, therefore, had a more profound PCOS phenotype (Table 1).
Because more severe metabolic abnormalities are present in individuals with IFG + IGT, diabetes develops more rapidly and unfavorable cardiovascular risk factors and mortality are increased compared with individuals with IFG only or IGT only (36– 36).
Further, women who were prescribed antipsychotics experienced greater weight gain and had more significant metabolic abnormalities than men (Seeman 2010; Softic et al. 2015; Wysokinski et al. 2012).
Non-diabetic patients with MetS had by definition more often metabolic abnormalities than those without MetS (Table 1).
This was expected because the IFG-IGT group has more severe metabolic abnormalities than the isolated states (15) and therefore has an increased risk of progression to diabetes.
More suggestions(15)
more severe abnormalities
more neurological abnormalities
more congenital abnormalities
more serious abnormalities
more somatosensory abnormalities
more metabolic capabilities
more metabolic depots
more metabolic routes
more complex abnormalities
more structural abnormalities
more Ca2+ abnormalities
more metabolic changes
more specific abnormalities
more physical abnormalities
more striking abnormalities
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