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Our results demonstrated that aMCI individuals displayed significantly more neurological abnormalities than normal controls on motor coordination, disinhibition, and the total NSS.
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In terms of topography, hemispheric injury is associated with more severe neurological abnormalities while global pervasive developmental deficits were far more common in patients with injuries to the vermis [ 25].
Polyneuropathy, fatigue and mild depression were common, but more severe neurological abnormalities were absent.
This is consistent with the observation that the patients with XPA mutation(s) more frequently exhibited neurological abnormalities.
Another possible bias is expectation bias, referring to the possibility that clinicians identify neurological abnormalities more often in infants with abnormalities on cranial ultrasound.
The goal of the current studies was to delineate more comprehensively the spectrum of neurological abnormalities in an international multi-centre study of a large group of LND variants.
The spectrum of patients referred is also subject to a strong referral bias as children with respiratory disease and neurological abnormalities were more likely to be referred for evaluation.
In the neuronopathic forms [types 2 and 3; both also referred to as neuronal GD (nGD ], which are much more rare than type 1, neurological abnormalities are observed in addition to visceral symptoms.
Patients with neurological abnormalities were not more likely to have swallowing abnormalities than those without (p = 0.64).
Dogs with inter-ictal neurological abnormalities were 16.5 times more likely to have an asymmetrical structural cerebral lesion and 12.5 times more likely to have a symmetrical structural cerebral lesion than IE [ 24].
Nevertheless, postulated mechanisms for how early biological risk might affect mental health in childhood include increased cell death from postnatal complications [ 19] or minor neurological abnormalities [ 22] but more research could be instructive.
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