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The more severe alterations in RAM morphology in the rpt5a mutants compared with rpn8a/heb3 mutants exposed to high-B were consistent with the finding that the rpt5a mutants were highly susceptible to high-B stress as indicated by root growth.
That patients with more severe alterations might have greater improvement in microcirculation parameters in response to a fluid challenge would in fact be expected from a physiologic standpoint.
More severe alterations are present at an age of about 28 to 29 months.
By further increasing the doses, more severe alterations of vascular development were observed with both morpholinos.
Since our previous work also showed more severe alterations in the Ts65Dn model, that bears Dyrk1A in trisomy [27], [28], the present results support the notion that Dyrk1A is involved in spatial learning in a dosage-sensitive manner.
In the current work we compared the effects of immobilisation on the knee and elbow joints in the chick and found that the elbow joint showed similar but no more severe alterations (not shown) highlighting a clear and intriguing difference between avian and mammalian models.
Similar(51)
These items were summed up to an already previously used taste alteration subscale (higher values indicating more severe taste alterations) (Zabernigg et al, 2010; Giesinger et al, 2011; Gamper et al, 2012).
The score ranges from 0 to 100 points, with higher values indicating more severe taste alterations.
Other techniques have been implemented to identify more severe histopathological alterations.
Patients who developed AKI not only took longer for ROSC, but also more frequently had pre-existing cardiac and renal disease, had more severe hemodynamic alterations, a more positive fluid balance and received more nephrotoxic agents.
Additional electron microscopic investigations in our patients' muscle tissues revealed a spectrum from mild to more severe pathological alterations including giant mitochondria, subsarcolemmal accumulation of mitochondria, globular inclusions, concentric cristae formation, cristae fragmentation, and crystalloid inclusions.
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