Sentence examples for more lethal phenotype from inspiring English sources

Taken together, the authors concluded that type 2 diabetes is a more "lethal phenotype" than type 1 diabetes.

An insidious but common environmental pollutant like cadmium that could potentially drive human prostate cancer progression to a more lethal phenotype deserves further study.

As compared with type 1, type 2 demonstrated to present to be associated with a more lethal phenotype and a higher mortality.

Progression and transition to a more lethal phenotype, which is distinguished by tumor growth at minimal levels of testosterone (<50 ng per deciliter) is known as castration resistant prostate cancer (mCRPC).

Young-onset T2DM is the more lethal phenotype of diabetes and is associated with a greater mortality, more diabetes complications, and unfavorable cardiovascular disease risk factors when compared with T1DM.

In contrast to a requirement for Smn in both muscle and neurons at the NMJ, we demonstrated that muscle specific reduction of Smn causes a more severe lethal phenotype (Figure 3B C).

However, it appears that loss of SMN activity in the muscle causes a more severe lethal phenotype (Figure 3B), a conclusion that is consistent with the finding that the SMN protein is concentrated in the post-synaptic regions in muscle (Figure 1A D).

In this regard, it is important to note that gene inactivation studies on Dohh have revealed a mild effect on the phenotype in yeast (Park et al., 2006) and a more pronounced lethal phenotype in Drosophila (Patel et al., 2009).

However, the mice exhibit a much more severe, lethal phenotype, which may be due to a higher surface to volume ratio as compared with humans, leading to excess loss of water through the skin.

In humans, numerous mutations in ITGB4 have been reported to cause JEB with truncating mutations being associated with a more severe (and mostly lethal) phenotype [ 22].

Since knockout models for GWAS-derived genes are more likely to express a lethal phenotype compared to mouse models for all other genes, it is plausible that that the GWAS-derived genes may be involved in important developmental and physiological processes.