Sentence examples for more normal phenotype from inspiring English sources

Antisense suppression of OsPIP1 1 causes partially defective phenotypes during seed germination, but overexpression of that gene does not stimulate the occurrence of a more normal phenotype.

Our results indicate that both NAF and CAF have the ability to inhibit epithelial cell proliferation and to induce glandular differentiation to a more normal phenotype.

We show how these cells can differentiate toward a germ line different from the original one, modifying their morphology and acquiring metabolic changes which are distinctive of a more normal phenotype.

Furthermore, MCF7 cells injected together with human fibroblasts in the fat pad of mice show a more normal phenotype (with lumen formation), when CEACAM1 is stably expressed in these cells [ 44].

Within 24 h of treatment, drug action is characterized by morphological reversion of tumour cells to a more normal phenotype (dendritic morphology), and rapid and reversible acetylation of histone H4 in both tumour and normal cells.

Indeed, our observation that preneoplastic lesions disappear from the glands of Copenhagen rats indicates that cell loss may be occurring, although redifferentiation of preneoplastic cells to a more normal phenotype is also plausible, as we have previously hypothesized [ 4].

Second, surprisingly our initial experiments demonstrated that 200 mM methyl sulfone induced contact inhibition and therefore might prevent progression of the disease by inducing more normal phenotypes and fewer metastatic phenotypes in melanoma cells.

We also generated direct fusion gl-TauS2A lines, which also consistently had more normal phenotypes compared with those derived using wild-type tau (Supplementary Material, Fig. S1).

We showed that Herceptin inhibited ErbB2 signaling in the 10A L2 cells, and reverted the aberrant 10A L2 acinar phenotype to a more-normal phenotype, suggesting that the LOXL2-induced effect on acinar morphogenesis was due to ErbB2 signaling.

Activated caspase-3, Ki67, and GM130 staining revealed that 10A L2 acini reverted to a more-normal phenotype when treated with lapatinib, confirming our findings with Herceptin, and showing that inhibition of ErbB2 blocks LOXL2-mediated formation of aberrant mammary acini.

A reversion to a more normal collagen phenotype, measured as an increase in fibril diameter and restored fibrillar architecture, and a decreased rate of collagen turnover were seen in cells expressing the ribozyme multimer.