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In another comparative fMRS study between patients with MwA and migraine patients with both visual symptoms and paraesthesia, paresia and/or dysphasia (but not MwoA), a PS-induced Lac/NAA increase was reported only in the migraine patients with the more complex phenotype (i.e., visual and other symptoms) while no changes were observed in the MwA and control group [14].
In order to provide an example of the effects of eliminating different segments of the population on a more complex phenotype, we examined hippocampal weight, a phenotype we have measured and published on before [12], [13] which has a particularly reliable QTL on distal Chr.1, which is also detected in the AIL population.
Unlike the more complex phenotype of the dominant ju89 single mutants, the severe loss of synapses in the ju89; tbb-1 gk207 tbb-1 gk207ant andoubledecrease in synapses in tbb-2(gk130) loss-of-function animutantTande 1) appears thebe causedecreaseectine axon outgrowth.
Mannose and xylose utilization presented a more complex phenotype.
Again, alcohol dependence in humans is a much more complex phenotype.
Therefore, Fgf23 −/− /VDRΔ/Δ and Kl −/− /VDRΔ/Δ compound mutants develop a more complex phenotype than Gitelman's syndrome.
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This includes detecting genetic polymorphism that is causative of phenotype and understanding how genetic variation alters the regulatory network, cell decision and more complex phenotypes.
Although cell-free directed evolution methods have been used to engineer proteins for nearly two decades, selections on more complex phenotypes have largely remained in the domain of cell-based engineering approaches.
Moreover, this approach is easily extendable to other omics applications and more complex phenotypes.
Even a GWAS performed for presumably more complex phenotypes such as canine compulsive disorder (similar to human obsessive-compulsive disorder) has rendered promising results in a single genomic region [10].
Since miRNAs are regulators of large molecular programs, they define much more complex phenotypes.
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more complex preparation
more benign phenotype
more apparent phenotype
more elongated phenotype
more complex way
more extreme phenotype
more mesenchymal phenotype
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more subtle phenotype
more aggressive phenotype
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more differentiated phenotype
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more normal phenotype
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