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We theoretically design less strained tricyclic molecules by replacing some carbon atoms with phosphorus atoms.
It can be inferred that Tb ions joined the molecules by replacing H atom of –OH, O = C OH or breaking the C O C band.
A control experiment was performed for each of the 14 small molecules by replacing the 75 μL of GO with pure Milli-Q water.
The synergistic agent TOPO and the micelle-forming detergent Triton X-100 further protects the Ln(BFPP 3 complex from fluorescence quenching water molecules by replacing them at remaining coordination sites in the complex and by solubilizing the complexes in micelles.
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BROOD is a software tool which explores chemical space around query molecules based on shape similarity and electrostatics, and it generates analogs of a reference molecule by replacing a selected moiety with fragments from in silico fragment databases.
In the subsequent structure activity relationship study, a new analog ZJ-109 was designed and synthesized to probe the importance of the lactone moiety of the molecule by replacing the lactone in ZJ-101 with a lactam.
In the subsequent structure activity relationship study, two new analogs, ZJ-105 and ZJ-106, were designed and synthesized to probe the importance of the conjugated trienyl lactone moiety of the molecule by replacing the C2 C3 double bond in ZJ-101 with a single bond and switching the geometry of the C4 C5 double bond in ZJ-101 from Z to E, respectively.
Therefore, it may be possible to increase ligand potency by improving interactions with these solvent molecules or by replacing them appropriately.
To resolve the poor discriminating ability of TO among tertiary structures of DNAs, a planar and rotatable π conjugated small molecule designed by replacing the methylene bridge with an ethylene that slightly increases its structural flexibility, while maintain the crucial conjugated co-planar two-ring system.
Based on the structural features of its crystals at room temperature, we hypothesized that introduction of a molecular spacer between two hydrogen bonded molecules of probenecid, by replacing the carboxylic acid homodimer with similar dimeric hydrogen bonding synthon, would not disturb the layered molecular packing of probenecid.
According to its design principle, the as-designed hydrogel was also tested to possess the generic detection function for other molecules by simply replacing its recognition element, which is expected to lay a foundation to realize the assembly of functionalized hierarchical graphene-based materials for practical applications in analytical field.
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atoms by replacing
models by replacing
genes by replacing
molecules by removing
compounds by replacing
molecules by altering
sequences by replacing
molecules by exchanging
molecules by adding
molecules by using
molecules by reusing
molecules by preventing
molecules by generating
molecules by observing
molecules by conjugating
molecules by folding
molecules by sharing
molecules by combining
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