Once in the lymph node, peptides could load directly at the cell surface of immature DC as previously reported, either on empty MHC class II molecules or by exchanging with previously loaded peptides at the plasma membrane or in early recycling compartments [44], [45].
However, in order to reduce the potential immunogenicity of the human molecule and to maximize the opportunity to maintain exposures in chronic models, a murine surrogate molecule was constructed by exchanging the human IgG1 Fc sequence portion of sotatercept with its murine IgG2a homolog.
3-dimensional domain swapping is a mechanism where two or more protein molecules form higher order oligomers by exchanging identical or similar subunits.
POPS and PIP2 molecules were subsequently incorporated into the equilibrated POPC bilayer by exchanging them for POPC molecules; this procedure was implemented using an in house lipid exchange script [30].
The pharmacokinetics of 99mTc-HYNIC-AMDP may be improved by exchanging one tricine molecule for another molecule, such as one of the pyridine derivatives.
The assembly of this vesicle is initiated by an enzyme from the Arf family, but the enzyme must first undergo a conformational change (by exchanging a molecule of GDP for one of GTP) before formation can begin.
The IPM regulates the interaction between RPE and photoreceptors by exchanging nutrients, signaling molecules, and metabolic end products [4].
Single cells achieve these necessities by exchanging gases and small molecules directly with their environment by diffusion.
Cell adhesion molecules control cell behavior through interactions with each other and with their microenvironment by exchanging information through cell-cell and cell-extracellular matrix (ECM) interactions [ 1].
The photocurrent retardation of ChR1 was overcome by exchanging the sixth helix domain with its counterpart in ChR2 producing Channelrhodopsin-green reChRGRr (ChRGR) with further reform of the molecule.
