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The combination prevents the aggregation of euglobulin molecules by preventing the formation of salt bridges between them.
Thus, although the modified calcium concentrations release more MEKK2 molecules by preventing their interaction with the cytoplasmic Lad1, the free molecules do not shuttle to the nucleus, possibly because of the calcium effects on nuclear pore proteins [55].
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We showed previously that mutation of Val to histidine inactivates the protein [ 2], and we suggested that steric clashes between His and Tyr could mimic the effects of the small molecule allosteric inhibitors by preventing insertion of the elbow region of active site loop 3 [ 11].
A mutation in the allosteric site of the caspase 3 dimer interface of Val to histidine abolishes activity of the enzyme, and models predict that the mutation mimics the action of small molecule allosteric inhibitors by preventing formation of the active site.
A scanning electron microscope (SEM) observation from the PMMA substrate surface and cross section, with and without the DLC coating and before and after the immersion into acetone, suggested that the DLC layer protected the dissolution of PMMA into acetone by preventing the molecules of acetone from contacting with the surface of PMMA and penetrating into the PMMA.
The immunoprobe offers several advantages as follows: (1) thionin can be enriched for signal amplification; (2) the catalysis ability of hemin can be enhanced by preventing the molecules aggregation; (3) the reduced graphene oxide-hemin (H-rGO) acts as signal amplifier to accelerate the redox cycling with H2O2; (4) the composite with good conductivity is beneficial to improve response current.
Since high levels of MeCP2 can repress cell surface expression of MHC class I, at least in neuronal cell lines, MeCP2 overexpression might result in an overrepression of MHC gene expression in the CNS, which may contribute to certain pathologies by preventing MHC molecules from fulfilling their roles during CNS development and in synaptic plasticity [51].
It is tempting to speculate that the first polypeptides could protect the RNA molecules from metal-catalyzed cleavage by preventing the binding of Zn2+ ions to the 2'-OH groups of ribose.
Ischemia-modified albumin (IMA) has the capacity to bind cobalt and other metal ions, a property that contributes to the anti-oxidant activity of albumin by preventing these molecules from catalyzing pro-oxidative reactions.
The reduction of these molecules by GSTs prevents further oxidant damage within cells.
Here, we describe our approach for the design and testing of small molecule transcription inhibitors that work by preventing the interaction between the essential transcription initiation factor σ and RNAP.
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