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CDHA modulated cell cycle regulatory proteins and apoptosis-related proteins in a manner similar to that of parent DHA.

Resveratrol also inhibited cell growth and modulated cell cycle in several human cancer cells (Mgbonyebi et al, 1998; Ferry-Dumazet et al, 2002).

The methanol extract perturbed cell cycle progression, modulated cell cycle and regulated, signal molecules were involved in induction of apoptosis in HepG2 cells.

One previous study demonstrated that inhibiting GPC3 expression released hepatocyte carcinoma cells from G1 arrest and thus modulated cell cycle progression in this type of cancer [ 45].

When combining concentration of 200 nM doxorubicin and 100  μM hesperidin together in treating with MCF-7 cells, they increased cytotoxic effect, modulated cell cycle, and induced apoptosis of MCF-7 cells [ 42].

Similar to that observed in ER α-positive MCF-7 breast tumour cells, RES inhibited DNA synthesis and modulated cell cycle progression in androgen receptor (AR -positive LNCAR -positiven AR-negative DU145 human prostate tumour ceLNCaPHsieh and Wu, 1999; Kuwajerwala et al, 2002).

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Panobinostat modulated cell cycles and angiogenic genes.

In addition, these data are consistent with other reports demonstrating that cyclin A is critical for c-Myc-modulated cell cycle progression [ 26].

These data indicate that these specific kinases are likely to be involved in improved radioresistance at ECM presence, in ECM-modulated cell cycle progression and the expression of cyclin D1 and pRb.

In addition, frankincense essential oil modulated expression of cell cycle regulator proteins, cdk4 and cyclin D1 (crucial cell cycle regulators), in pancreatic cancer cells.

Tripathi et al. found that lncRNA MALAT1 modulated expression of cell cycle genes and was required for G1/S and mitotic progression [ 16].

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