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We showed that loss of IKKβ in fibroblasts led to TGFβ activation, which in turn modulated cell motility, myofibroblast transformation and senescence.
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We use the unique characteristics of small molecules to probe and selectively modulate cell motility.
Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.
Stein, J. V. T cell motility as modulator of interactions with dendritic cells.
Sheetz, M. P. & Dai, J. Modulation of membrane dynamics and cell motility by membrane tension.
As over-expression of SphKs or down-regulation of S1PL modulated S1P-induced human lung EC migration suggesting a potential role of SphKs and S1PL in cell motility, in the present study, we examined the role of SphKs and S1PL in human lung EC motility.
Likewise, modulated genes include genes involved in cell-cell interaction or adhesion (CD44, NCAM1, integrins, cadherins and protocadherins) and cell motility processes (regulation of actin cytoskeleton, myosin), such as genes that regulate or act along the Rac1 and CDC42 RhoGTPase signaling pathways.
We also found that anosmin-1 enhanced proliferation and motility of glioblastoma cells in vitro, formed a complex with integrin β1 inducing downstream signaling, and modulated cell adhesion.
Ashmore, J. Cochlear outer hair cell motility.
Wall, D. & Kaiser, D. Type IV pili and cell motility.
Increased cell motility is a fundamental characteristic of cancer cells1.
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