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A comparison of Figure 3a and 3d revealed that the time-course of the effects of VPA on the degree of Erk1/2 phosphorylation resembled that observed for the inhibition of cell speed, suggesting that VPA partially modulated cell speed through modulation of the degree of Erk1/2 phosphorylation.
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This not only suggests that cardiomyocytes are the preferentially modulated cell type, but also provides further evidence for the identified mechanistic fingerprints.
The directional extension of lamellipodia on both surfaces modulated cell morphology, resulting in a fibroblast-like morphology.
Specifically, ADAMTS-12 modulated cell invasion by regulating the expression and function of the αvβ3 integrin heterodimer.
Panobinostat modulated cell cycles and angiogenic genes.
In this study, we observed that TSG101 depletion bidirectionally modulated cell invasion but not cell migration in different cell types.
In summary, we found that TSG101 bidirectionally modulated cell invasion through regulating MMP-9 mRNA expression in different cell types.
CDHA modulated cell cycle regulatory proteins and apoptosis-related proteins in a manner similar to that of parent DHA.
Stuffing modulated cell-mediated immunity by reducing lymphocyte proliferative responses to T-cell mitogens during early lactation.
Information about stimulus location in head-centered coordinates is distributed across such a population of modulated cells.
The mechanism of differential reactivity was cell-intrinsic and modulated by cell metabolic activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com