Sentence examples for modulate the extracellular from inspiring English sources

This study reveals for the first time that MSC can alter the expression of several types of collagen and thus potentially modulate the extracellular matrix and stroma, which may at least partially explain the anti-cancer activity of MSC.

In principle a Na/HCO3 transporter could modulate the extracellular HCO3− concentration in response to horizontal cell polarization and mediate in that way negative feedback from horizontal cells to cones.

It is also proposed that the enzyme could modulate the extracellular matrix in the vessel wall affecting the downstream tissue-remodelling processes, associated with atherogenesis.

Two mechanisms to modulate the extracellular concentration of IGF1 were examined: cell-mediated depletion of ligand and extracellular sequestration by IGFBPs.

In addition to the IL-6 signaling pathway, TG2 can directly modulate the extracellular matrix (ECM) structure [ 45], activate focal adhesion kinase via binding with integrins [ 35], and activate growth factors such as TGF-β [ 46], a key inducer of EMT, buried in the ECM networks, and thus may affect a broader aspect of tumor biology.

Opioid addiction modulates the extracellular signal-regulated kinase (ERK) leading to synaptic plasticity in the brain.

However, in the delayed phases after injury, MMPs and other proteases may also play beneficial roles by modulating the extracellular matrix (ECM) and trophic factors in the brain parenchyma and at the neurovascular interface [11], [17].

Second, vitamin D may prevent aggressive breast cancers by modulating the extracellular microenvironment, as vitamin D has been shown to alter the expression of a variety genes involved in extracelluar matrix remodeling [39], [40] and to modulate breast cancer phenotypes [41].

Extracellular proteolysis represents a potent and irreversible mechanism modulating the extracellular matrix and tissue remodeling, which can affect the breakdown of the BBB.

Malignant tumour cells have a critical role in modulating the extracellular environment and there is evidence that this is advantageous for tumour invasion and metastases.

It has been demonstrated that LRP1 modulates the extracellular levels of several matrix metalloproteinases [ 4, 5] as well as the extracellular level of urokinase plasminogen activator (uPA), a serine proteinase that activates plasminogen [ 2].