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miRNAs targeting these enzymes or regulators have been shown to modulate the reprogramming process.
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In the same way, the approach can be used to reprogram a metabolic strategy to modulate the effect of temperature on bacterial toxicity.
Hence, selective chromatin modifiers could modulate the complicated transcriptional network, with less exogenous transcription factors, thus efficiently reprogramming somatic cells.
We discuss how lipid scavenging can be mediated via the reprogramming of cellular transporters at these interfaces and describe recent data suggesting that pathogen effectors modulate the formation of specific membrane contacts.
Mohamed et al. screened a library of 5,500 small molecule compounds in an unbiased, high throughput approach to determine cell signaling pathways that modulate reprogramming and identified the WNT and TGFβ signaling pathways as barriers to reprogramming (Mohamed et al., 2016).
In our previous study to delineate the underlying mechanisms that modulate the inflammatory response after TLR stimulation, we showed that prior exposure of HCECs to flagellin results in tolerance and cell reprogramming in HCECs [30].
To systematically identify miRNAs that can modulate the iPSC production, Judson et al. screened 570 chemically-synthesized mature mouse miRNA mimics for their ability to promote OSK-induced reprogramming of mouse embryonic fibroblasts (MEFs) (Judson et al., 2013).
It helps modulate the speed of neurotransmission.
The above curves modulate the Filter 2 cutoff.
Thus, in the appropriate transcription factor context, Nanog levels can modulate reprogramming up to maximal efficiency.
Somatic and pluripotency TFs modulate reprogramming efficiency when overexpressed by altering OSK targeting, somatic-enhancer inactivation, and pluripotency enhancer selection.
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