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In addition, nanotopography has also been seen to modulate the bone mineralization [24].
TiO2 nanotubes can modulate the bone formation events at the bone-implant interface to reach a favorable molecular response and osseointegration [29].
These findings suggest that TWEAK may modulate the bone erosion associated with several diseases, such as rheumatoid arthritis (RA) and multiple myeloma.
Animal physical activity levels should also be considered and quantified where possible, as these also modulate the bone repair process [ 52].
The formation of sclerotic subchondral bone in OA (1, 2) has also been linked to alterations in growth factor signaling, particularly insulin-like growth factor 1 (32– 35), as well as the urokinase plasminogen activator/plasminogen system (32, 34), both of which may modulate the bone matrix.
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<8 (better) >8 (poorly) 10.7 ± 5 16 better, 16 poorly, 19 control 51 1 100 Poor glycemic control negatively modulated the bone factors during healing, although diabetes (regardless of glycemic control) had no effect on implant stabilization.
We have recently demonstrated that heparanase modulates the bone marrow (BM) microenvironment as well as basic features of hematopoietic stem and progenitor cells, including development, proliferation and retention [31].
EL may have achieved this by modulating the bone resorptive activity of osteoclasts [ 8].
The binding of RANKL to RANK leads to osteoclast differentiation and activation; RANKL inhibition modulates the bone microenvironment by inhibiting osteoclast-mediated bone destruction.
To test the hypothesis that oestrogen-deficiency induced by OVX modulated the bone response to particulate debris, we supplemented PE particle-implanted OVX mice with 17β-estradiol.
Osteoblasts can regulate bone metabolism by modulating the bone resorption process, directly via the production of receptor activator of nuclear factor κβ ligand (RANKL) and negatively via the secretion of its decoy receptor Opg [ 45, 46].
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