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Although DNA polymerases can modulate the backbone position of the templating nucleotide, perturbing the position of the α-phosphate of the incoming 8-oxodGTP to accommodate an anti conformation would be expected to severely compromise its insertion.
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Random vibrations of amino acid side chains modulate the distance between the Trp residue and the backbone, as well as the local electric field.
Whether and how these three disordered sequence elements interact with each other, through the peptide backbone and through space, to define or modulate the solution properties of HTT exon1 is a challenging problem that is only beginning to be explored.
E303 also appears to modulate the positive charge density of the active site that is used to anchor the phosphate backbone of the substrate during catalysis.
We modulate the temperature.
It helps modulate the speed of neurotransmission.
The above curves modulate the Filter 2 cutoff.
Dietary nutrients modulate the same genes.
The backbone carbonyl groups of D1-pheylalanine 182 and D1-aspartate 170 orient two key waters in a diamond cluster that H-bonds with TyrZ, which may modulate the p Ka of TyrZ (see Figure 3).
The canvas grins through, modulating the whiteness.
Saccharin directly modulates the microbiota.
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