Sentence examples for regulate the bone from inspiring English sources
Bone normally undergoes continual remodelling and two types of cells are involved: osteoblasts (these make and regulate the bone matrix) and osteoclasts (these absorb bone matrix).
We then showed that grafted hBMSC survival is crucial as cells participate directly to bone formation and play a paracrine action via the secretion of hIGF1 and hRANKL which are known to regulate the bone formation and resorption pathways respectively.
Chronic inflammation seems to play a role in some patients and there is evidence that inflammatory cytokines may down regulate the bone marrow response to erythropoietin [10], [11].
Recently, some studies have noted that HIF-1 α can regulate the bone formation ability of osteoblasts in postmenopausal osteoporosis.
Indeed, Tbx1 is able to negatively regulate the bone morphogenic protein Smad1 pathway by binding Smad1 and thus preventing the Smad1 Smad4 interaction (18), which is required for the activation of Smad1 target genes (19).
The ability of peptidergic nerve fiber to regulate the bone formation can be used to construct the neurotized tissue-engineered bone by embedding the sensory nerve fiber into the center of bone graft [ 12– 12].
In summary, we demonstrated that T3 regulates the bone formation process by up-regulation of collagen and of enzymes important of collagen-fibre formation.
On the other hand, the proteasome pathway also regulates the bone formation.
We are still to determine the importance of the neutrophil in regulating the bone destruction that occurs in RA and other chronic inflammatory conditions.
Finally, the nodal signaling pathway regulates the bone morphogenic protein pluripotency pathway [ 69], which was previously shown to play an important role in the development of GCT [ 70].
It has been shown that leptin regulates the bone clock through sympathetic nervous system and Adrb2 (β2-adrenergic receptor) present on the osteoblasts, thus linking global metabolism and the bone peripheral clock.
