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Specifically, phonotrauma can (1) alter the tissue's physical properties by disrupting intracellular adhesion [1], and (2) modulate the tissue's cellular/molecular responses by altering gene expression [3].
The antifibrotic actions of pirfenidone and other data suggest that pirfenidone could modulate the tissue response to injury at multiple stages of wound repair to improve scarring and function as an adjuvant for abnormal wound healing processes.
Moreover, SASP can directly modulate the tissue microenvironment, elicit immune surveillance of senescent cells, and paradoxically, promote tumorigenesis by supporting the proliferation of surrounding malignant or pre-malignant cells [ 1].
Several recent reports have suggested that massage-based therapies can modulate the tissue's inflammatory and immune responses [ 4– 6].
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Soft bioengineered surfaces offer a route towards modulating the tissue responses to chronically implanted devices and may enhance their functionality.
In conclusion, L. monocytogenes infection modulates the tissue distribution of Ly49s3+ NK cells, and induces increased MHC class I expression and hence reduced surface expression of Ly49 receptors on NK cells.
Recent studies suggest an association between chronic inflammation, modulating the tissue microenvironment, and tumor biology.
Herein, we demonstrated that Rapamycin protects the PM in PD, modulating the tissue fibrosis, MMT, Endo-MT, and especially angiogenesis and lymphangiogenesis.
Gut microbiota can also affect host metabolism and inflammatory state by modulating the tissue fatty acid composition: mammalian intestinal Lactobacilli and Bifidobacteria can synthesize from free linoleic acid bioactive isomers of conjugated linoleic acid, which have antidiabetic, anti-atherosclerotic, immunomodulatory, and anti-obesity properties (42).
The study also suggests that new opportunities might arise for the prevention or treatment of obesity-related metabolic complications if it were possible to modulate the adipose tissue lipid network to regulate membrane functional maintenance and/or the vulnerability to inflammation.
We cannot exclude that the degree of mosaicism present in the lymphoblastoid cell lines can modulate the overall tissue-specific expression levels of these genes.
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