Sentence examples for modification of receptor from inspiring English sources

Moreover, chemical modification of signalling proteins by ITCs may be complemented by modification of receptor proteins, as has previously been shown for the TRPA1 receptor [39], [40].

Early work characterizing the binding properties of the α7-nAChR showed that modification of receptor thiol groups and cleavage of disulfide bonds, important in the manifestation of affinity state changes, decreases the binding affinity of the receptor for agonists by 10-fold, shifting the dose-response curve to the right [77].

Thus, we conclude that a modification of receptor is not required to discriminate between the pathways.

Further, modification of receptor tyrosine kinases (RTKs) with N-glycans is known to control their surface presentation via the galectin lattice, and thus increased DPAGT1 expression likely contributes to abnormal activation of RTKs in oral cancer.

Oxidized lipids can mediate biological responses through two diverse mechanisms: classic reversible binding and irreversible covalent modification of receptors [ 15, 22, 24– 26].

In contrast, electrophilic PGs can also participate in cell signalling through covalent modification of receptors [ 22, 33], a signalling mechanism that will be discussed further below [ 23, 101].

Pascual and colleagues [ 14] demonstrate that SUMOylation at different sites confers different modifications of receptor activity and identify K365 as the SUMOylation site required for transrepression of inflammatory genes by PPARγ.

Considering the structure modification of GABAA receptor augment the receptor activity.

Actually, benzodiazepines bind to the gamma subunit of the GABAA receptor, due to which a structural modification of the receptor results in an increase in GABAA receptor activity.

While the core signalling pathway is simple, there is considerable complexity in the way that signalling is regulated through post-translational modifications of receptors and ligands [ 4 6].

A20 is a key regulator of NF-κB through ubiquitin modifications of receptor-interacting protein kinase (RIP) and tumor necrosis factor receptor-associated kinase 6 (TRAF6) [ 32].Multiple associations have been found in TNFAIP3 in a range of autoimmune diseases [ 28]; of these associations, rs2230926 has shown the strongest significance (P = 1.37×10−17, OR = 1.72) in SLE.