Sentence examples for change of receptor from inspiring English sources
The mechanism involved in the color change of receptor R1 is deprotonation of acidic –NH followed by stabilization of complex through intramolecular charge transfer (ICT) transition which was evidenced by the formation of HF2 peak in 1H NMR titration.
The color change of receptor R2 involves initial hydrogen bond formation of F− ion with –NH group and deprotonation at higher concentration of F− ions which leads to intramolecular charge transfer transition in organic media.
This makes a CB1-driven bias unlikely, however we cannot rule out a change of receptor activation due to receptor internalization.
On the basis of data collected regarding changes in plasma drug concentration in Japanese patients, as well as pharmacokinetic and pharmacodynamics parameters, we calculated the time-course changes of receptor occupancies (Ф1B and Ф1D).
In addition to changes of receptor expression in the lymphocyte compartment, myeloid and plasmacytoid dendritic cells also displayed temporal changes in the expression of ligands for costimulatory and inhibitory receptors.
Our results suggest that the [F]FBEM-ZHER2 Affibody radioconjugate described herein can be used to assess HER2 expression in vivo by PET imaging and, thereF]FBEM-ZHER2 Affibodyo monitoradioconjugatenges of receptor expression in response to therapeutic interventions.
The coupling of the PARs to either the G proteins or beta-arrestins is driven by ligand-triggered changes of receptor conformation that for other GPCRs is thought to involve the putative transmembrane helices 3 and 6 of the receptor [ 36, 37].
Hypothetically, our data may have resulted from temporal processes (e.g. changes of receptor sensitivities), where the oxytocin system in general changed its activity in opposite directions (due to e.g. genetic polymorphisms) among responders compared to non-responders, the net result being an increased activity.
It is possible that these differences reflect the type of lesion: after a constriction (i.e., application of a ligature) an increase in the expression levels is observed, while nerve injury or full axotomy leads to reduction or no changes of receptor expression.
From this point of view, flexible docking can decrease the ratio of wrong prediction by considering the conformational change of the receptor during the receptor-ligand binding process.
It is therefore possible that a decreased luminal pH might promote clustering or conformational changes of receptors that alter recruitment of cytosolic signal transducers.
