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Current Research and Scholarly InterestsLong-lasting changes in synaptic strength are important for the modification of neural circuits by experience.
As a consequence, magnetic resonance signal estimates brain activity related to the changes in blood flow that follow modification of neural activity.
On the other hand, the information of fuzzy cognitive map modelling is applicable for modification of neural networks structure for providing more accurate results based on the extracted knowledge from the cognitive map and visualization of the system's performance.
Hence, there is a clear correspondence between training-induced neural changes and the related behavior: when behavior improves after training, there is also a concomitant modification of neural activity, whereas in the present study there was no change in either behavior or brain activity.
However, the mechanism of dopamine contribution to the modification of neural representation is unclear.
Previous studies indicated that neuronal plasticity results in a cascade of modifications in structures following modification of neural input [ 6– 8].
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Bachtold, M.R., Rinaldi, P.C., Jones, J.P., Reines, F. & Price, L.R. Focused ultrasound modifications of neural circuit activity in a mammalian brain.
This was accompanied by electrophysiological and morphological changes consistent with the generation of "silent synapses," which provide an ideal substrate for further experience-dependent modifications of neural circuitry and which may also be important for the consolidation of long-term synaptic plasticity and memories.
The mechanism for modulating the neural responses could be experience-dependent (but not learning-dependent) modification of the neural responses (Messinger et al., 2005) or consistent modulation by attention (Maunsell & Treue, 2006; Nobre et al., 2006).
Poly sialic acid) (PSA), a homopolymer comprising 2,8-linked sialic acid residues, is a modification of the neural cell adhesion molecule (NCAM) that has been linked to neuronal plasticity.
A promising scaffold material for the application in tissue engineering or other biomedical applications is polysialic acid (polySia), a homopolymer of α2,8-linked sialic acid residues, which represents a posttranslational modification of the neural cell adhesion molecule and occurs in all vertebrate species.
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