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This finding suggests that the increased migratory propensity of LRP1-deficient SMCs, which is further enhanced by PDGF-BB activation of PDGFRβ, is in its entirety dependent upon the activation of PI3K by PDGFRβ.
This implies a higher migratory propensity of these cells.
In another gene, adenylate cyclase-activating polypeptide 1 (ADCYAP1), length of a microsatellite repeat predicts migratory propensity of both populations and individuals in blackcaps.
Our results showing that overexpression of MET causes downregulation of E-cadherin expression therefore implies a higher migratory propensity of these cells.
The hypoxic response includes activation of numerous factors associated with cell motility and cytoskeletal structure (Semenza, 2003), and hence Snail-dependent migration is only one of several mechanism suggested to link hypoxia to an enhanced migratory propensity of tumour cells.
Overexpression of Snail increased the motility of MCF-7, T-47D and MDA-MB-231 cells, whereas silencing of the protein resulted in decreased migratory propensity of MCF-7, MDA-MB-468 and MDA-MB-231 cells.
Similar(54)
Our goal in this study was to build upon previous candidate gene studies to determine whether or not similar genetic mechanisms explain variation in migratory propensity at the level of individuals, populations, and species across taxa.
Regardless of the mode of plasticity, however, the expression of alternative migratory and resident life histories could reflect any of several intrinsic mechanisms, including epigenetic variation influencing expression of genes underlying migratory propensity.
The transition of a cancer from a 'localized' tumor to a metastatic form requires the acquisition of several cellular transformations, including migratory propensity and invasiveness (Chaffer and Weinberg, 2011; Valastyan and Weinberg, 2011), and these transformations are strongly influenced by the surrounding normal, heterogeneous tissues.
In general, the analysis revealed that higher migratory propensity was associated with strong EMT traits and weak expression of a signature derived from normal small intestinal epithelium (i.e. SLC_SI3).
Even though some epidermal melanocytes resemble the transient amplifying melanocytic cells of the hair follicle with respect to their differentiation status, they are not thought to have the same migratory propensity.
Related(20)
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