Sentence examples for migratory action of from inspiring English sources

We analyzed the mechanism underlying the molecular switch from proliferative to migratory action of androgens.

Previously, moscatilin was reported to have antioxidant effect [ 12], and we further found that this substance reduced endogenous OH∙ and thus inhibited migratory action of the cells.

Next, we performed a wound healing assay to validate that YTZ3-15-delivered siRNA against TWIST1 not only reduces the expression of TWIST1 and its target genes, but also inhibits the migratory action of SUM 1315 cells.

We clearly show that by blocking the TGF-β pathway with LY364947, we could significantly hinder the migratory action of TERT-siSFRP1 cells ZEB2 was originally characterized as a Smad interacting protein (SIP) and regulator of TGF-β signaling [ 17].

In order to establish whether TGF-β signaling elicits a direct physiological consequence when SFRP1 is downregulated, we measured activated ERK1/2 levels and the migratory action of in TERT-siSFRP1 cells in response to TGF-βR inhibition.

Contribution of the SDF-1α/CXCR4 axis to the migration of cervix carcinoma cells was suspected; indeed a pro-migratory action of the SDF-1α has been reported in HeLa cells [43], [44].

While we have reported the inhibitory effect of CO on VSMC proliferation in the past, to our knowledge this is the first report of the profound anti-migratory action of CO in hypoxic vascular smooth muscle cells.

Given that the activities of Flt-1 and its downstream target pAkt are critical to VEGF165 signaling for chemotaxis [ 53, 54], the anti-migratory action of sFasL may be mediated by blocking VEGF165-induced upregulation of pAkt activity.

For example, peptide Ac2-26 retains most of the anti-migratory actions of AnxA1 [13], [13] however, using artificial transfected cell systems, peptide Ac2-26 has been shown to activate human FPR [14], [15] as well as the third receptor of this family, termed FPR-like 2 [14].

Thus, NRP-mediated pro-migratory action on MDA-MB-231 breast cancer cells is likely a consequence of endogenous VEGF-C binding.

Furthermore, we found that the increased migratory action was associated with the increased expression of caveolin-1 (Cav-1), which in turn activated the focal adhesion kinase (FAK) and ATP-dependent tyrosine kinase (Akt) pathways.