Furthermore, miR-31 was identified as a direct modulator of integrin-α(5) and RhoA, two critical activators of the migratory activity of fibroblasts [ 38].
In contrast, the migratory activity of neither naïve nor activated CTLs was influenced by normoxic or hypoxic cell culture supernatant, whereas the overall migratory activity of activated CTLs was higher than of naïve cells (27.4% ± 4.7% compared to 15.3% ± 14.3% migrating cells; Fig. 4B and 4C).
Ecological conditions play a great part in the migratory activity of mammals, who react to general food shortage by moving to another region.
In contrast, fibroblast factors increase the migratory activity of Schwann cells without being chemoattractive.
An autocrine PGE2-mediated migratory activity of these cells appeared to be associated predominantly with EP4 receptor-mediated signaling pathway, which uses cAMP as a second messenger.
The high accumulation of the CB-RBCMs in neurons resulted in a decrease in the neurotoxicity of CB and an increase in the migratory activity of neurons, and alleviated cognitive decline in APP/PS1 transgenic (Tg) mice.
In order to test the potential "intrinsic" difference in migratory activity of the two cell populations, the migratory activity of FPN hNSCs was espressed as fold increase to the migratory activity of EF hNSCs in each culture condition.
The migratory activity of BAEC was assessed using a wounded migration assay.
12 hours later the denuded area was again measured and the migratory activity of the endothelial cells estimated (Figure 3A).
We found that depletion of Cdc42 dampened migratory activity of SP thymocytes toward MIP-3β (Figure 2A).
The experiments performed suggest that the alterations in cell-cell interactions and the remodeling of AJs change motile behavior and migratory activity of transformed epithelial cells.
