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To test whether there were potential off-target cleavages in Tbx3-2A-GFP mice, we predicted 11 potential off-target sites throughout the genome containing up to three mismatches when compared with the 20 bp sgRNA coding sequence (Table S1).
Given the striking decrease in thymic cellularity in Lmna-/ mice, we predicted a decrease in the proportion of the predominant CD4+CD8+ double-positive (DP) thymocyte population.
Based on the intense reactivity of microglia in Plp1tg mice, we predicted the up-regulation of classical inflammatory markers.
Since Asns levels are higher in CD38-null mice, we predicted that asparagine levels would also be higher.
Having demonstrated that PGE 2 administration bypasses the phenotype of TLR4-/ mice, we predicted PGE 2 treatment might increase mucosal AR expression.
Based on the hierarchical relationship observed between H2B-LRCs and H2B-nonLRCs and the loss of self-renewal potential of juvenile SCs in p27 null mice, we predicted that p27kip1 function was restricted to LRCs.
Similar(53)
Given that many known oncogenes and tumor suppressor genes regulate T-cell lymphoma in mice, we predict that inhibition of the apoptosome will not significantly alter tumor formation in epithelial cells.
From this we make the following predictions: (1) under reduced Lis1 and enhanced DCX expression, we predict a reduced bipolar migration in rats, and (2) under enhanced DCX expression in mice we predict a normal or a higher bipolar migration.
Thus, if ASIC3 protein were abundantly expressed in mouse brain, we predicted that it would multimerize with ASIC1a.
Although, rods vastly outnumber cone photoreceptors in the mouse retina, we predicted that the Crx-expressing donor populations from early retinal development would contain a comparatively high proportion of cone precursors, as most rods are born relatively late.
Based on limited human or mouse data we predicted a correlation between loss of cavitation and a loss of tumour necrosis factor (TNF -α or inTNF -αor (interferon2– 24]; however, dIFN -γIFN -γ these cytokines in the non-cavitary group was modest and not statistically significant.
Related(20)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com