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Conversely, in Igf1−/− mice we defined DE genes as those that presented a negative FC less than -1 with an associated probability lower than 0.05.

Using the Rpe65R91W/R91W mouse, which carries a mutation in the Rpe65 gene leading to progressive photoreceptor degeneration in both patients and mice, we defined stages of retinal degeneration that still allow cone rescue.

In order to address this, and other similar questions in mice, we defined a general scheme for lineage analysis which assigns statistical significance to the correlations between lineage and various cell properties (see Results).

Using in vitro BBB models established from different genetically-modified mice, we defined the endothelial cell adhesion molecules mediating post-arrest T cell interactions and especially T cell crawling against flow on the BBB [ 5].

The validation (val†) column shows a star if the initial finding in female liver was replicated in the independent test set of 129 F2 male mice; we defined validation success as LEO.NB.OCA score above 0.3 using the default settings of automatic SNP marker selection.

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In mice, we define a variety of Zfy transcripts, among which is a Zfy2 transcript that predominates in spermatids, and a Zfy1 transcript, lacking an exon encoding approximately half of the acidic domain, which predominates prior to MSCI.

With the help of the mouse sequences we defined the corresponding rat orthologs from genomic sequences and adjusted the predicted gene models in GenBank for further phylogenetic examinations (see below).

In the brain of transgenic mice, we genetically defined a subgroup of glial progenitor cells in which the Plp1- and the Gfap-promoter are simultaneously active, giving rise to both astrocytes and NG2-positive glia.

To evaluate neoadjuvant therapy in mice, we first defined an optimal window for neoadjuvant therapy using four tumor models of spontaneous metastasis that involved orthotopic implantation of tumor cells followed by primary tumor resection.

In every mouse homologous region, we defined a CHAOS sequence as the sequence comprised of the conserved segments and other sequences at both sides to cover the entire human region.

Following our previous work (Liao et al. 2006), we defined mouse essential genes by knockout phenotypes of premature death or sterility (see Materials and Method).

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