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Based on the results of these experiments conducted using subcutaneous xenograft model mice, we decided to use cell line B, which showed both rapid tumor growth and high in vivo99mTcO4 – uptake levels (11.8-fold of line N), from the three stable cell lines for generating mouse orthotopic xenograft model.
To gain more insight in the regulation of prominin-1 in mice, we decided to study the prominin-1 SVs by analyzing their expression pattern on protein and mRNA in several mouse tissues.
Since our expression profiling analysis did not reveal any global transcriptional changes in either the endoneurium or the DRG of diabetic mice, we decided to evaluate the expression of selected genes previously shown to play an important role in development or maintenance of these compartments.
Given that chronic β-blockade did not prevent VT in male Mecp2 Null/Y mice, we decided to test the female Mecp2 Null/+ mouse model of RTT.
Since, up to now, there are no data available on the biodistribution of any anti-CEA IgM in mice, we decided to analyze the biodistribution of our VG-IgM in LS174T tumor bearing nude mice.
Due to the severe phenotype of Ercc1 knockout mice, we decided to employ mice expressing the hypomorphic Ercc1 allele (Ercc1 -/Δ ) as a putative model for glomerular aging biology [ 13, 28].
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Since the characterization of the published iPSC lines are usually more thorough in mouse, we decided to test our hypothesis on the mouse iPSC lines.
We noticed that Clock −/− mice developed dermatitis at a higher frequency than wild type mice; therefore, we decided to carefully monitor dermatitis development similarly to the development of cataracts.
However, since 100% of non-exposed PbA-infected mice died, we decided to evaluate whether the reduction on parasitemia levels in HBO exposed animals could be sustained over longer periods.
Since we have previously shown that overexpression of Bcl-2 can rescue the defect in positive selection of conventional αβ T cells observed in Egr2f/f-lckCre mice [20], we decided to test whether Bcl-2 could also rescue generation of iNKT cells.
Having established that liver stage infection can be accurately and conveniently measured in vitro and in vivo by assessing the luminescence of PbGFP-Luccon-infected cells or mice livers, we decided to investigate the suitability of this method for the evaluation of anti-plasmodial drugs.
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