Sentence examples for mice develop normal from inspiring English sources

Given the dramatic effects GOF mutations has on bone development, it seems paradoxical that trpv4−/− mice develop normal skeletons at birth [39], [42].

These data coupled with the fact that TA-specific knockout mice develop normal skin add further credence to the idea that ΔNp63 might be the critical p63 isoform required for epidermal morphogenesis [22].

Note that MHC class I restricted OT-1/Itk−/− mice develop normal conventional CD8+ T cell due to efficient selection in the thymus of T cells carrying this transgenic TCR [23].

We further show that HPK1−/− mice develop normal bone marrow and splenic B-cell subset counts but exhibit an increase in B-cell reactivity, suggesting that HPK1 limits the actions emanating from the SKAP-HOM adaptor complex needed for proper B-cell activation and adhesion.

Surprisingly, whereas heterozygosity of specific CRX mutations in humans can cause severe retinal disease, Crx +/− mice develop normal photoreceptors that do not degenerate (Furukawa et al., 1999).

Although Bcl-G-deficient mice develop normal and display no obvious phenotype under steady state conditions, the function of Bcl-G under pro-inflammatory conditions and in tumor development remains to be explored in appropriate model systems.

In contrast, IL-12 KO or IFN-I receptor KO mice developed normal levels of specific cytotoxicity in vivo (Fig. 6A and 6C, respectively).

Indeed, analysis of these mice 5 9 days after infection showed no detectable parasites in peripheral blood, whereas control mice developed normal blood infections with parasitemias ranging between 0.1 and 3% at day 4 post-infection.

Bik-deficient mice develop normally with a normal lifespan.

Alk7ASKA mice developed normally, and displayed normal growth and normal fasting insulinemia and glycemia (data not shown).

T cells from triple-mutant mice developed normally and showed normal cytokine secretion and proliferative responses to TCR stimulation.