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These mice develop multifocal adenomas early in adulthood.
SP-C C-Raf BxB mice develop multifocal adenomas early in adulthood.
A recent mouse model for RMS has been described by Sharp et al (2002) who report that HGF/SF Ink4A/Arf−/− mice develop multifocal sarcomatous malignancies arising from trunk and limb skeletal muscles.
Female MMTV-PyMT mice develop multifocal mammary tumors (Guy et al. 1992) and have been used as a murine model resembling human breast cancer (Gendler and Mukherjee 2001; Maglione et al. 2001).
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TGF- β null mice developed multifocal infiltrates in heart, lungs and salivary glands [ 18, 52].
The mice developed multifocal bronchioalviolar neoplasias very rapidly and often died before four months of age, making investigation of the early events in carcinogenesis difficult.
These changes are not typically observed in the transgenic primary tumor model, as the mice develop large multifocal luminal tumors that necessitate euthanizing the mice before these genetic and epigenetic alterations take place.
Mice heterozygous for a C-terminal truncation mutation, Apc+/1572T, develop multifocal mammary tumors with pulmonary metastasis at much higher frequency (Gaspar et al., 2009).
After intensive chemotherapy granulocytopenic patients can develop multifocal osteomyelitis.
MENX-affected rats develop multifocal pituitary adenomas in the anterior lobe of the gland.
As a consequence of SV40 early gene expression, parous WAP-T mice develop multiple alveolar lesions – multifocal intraepithelial neoplasia (MIN).
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