Interestingly, while APC mutated mice develop low-grade adenomas, the development of tumours in the APC/netrin-1 mice was pushed towards high-grade adenoma and adenocarcinoma (Mazelin et al, 2004).
Over 88% of Lrig1 Cre/Cre mice develop low-grade duodenal tumours overlying significantly expanded Brunner's glands; levels of ErbB1-3 and p-Erk1/2 in these tumours are higher than in matched grossly normal small intestinal tissue.
At the first challenge after drug treatment, some mice developed low levels of parasitemia (<10%) in both groups, and all self-cured within 7 days (data not shown).
Since all PIN lesions showed marked nucleolar enlargement, similar to human high grade PIN, we propose to refer to these lesions as high grade PIN and we submit that Lo-MYC and Hi-MYC mice do not develop low grade PIN.
infection with VACV-WR simulates the spread of smallpox virus throughout the respiratory tract with subsequent spread to other visceral organs such as the ovaries, spleen, lungs, and liver [5] [7], but mice develop a low primary immune response.
TRP mice develop diffuse, low-grade astrocytomas following induction, which is followed by progression to high grade astrocytomas that are histologically similar to human GBM after 4 to 6 months (Miller et al., 2009; Motomura et al., 2012; Schmid et al., 2012).
Following the challenge, control mice also developed low levels of IgG (GMT ≤ 2.5 log10) and IgA (GMT 2 log10), but the titers were significantly lower than those of the vaccinated mice (p < 0.001).
We have previously reported that thyr-IFNγ transgenic mice develop primary hypothyroidism (low T4, high TSH, and low iodine uptake) [5], goiter [6], and growth defect [6].
Consistent with the association study, when Wls was specifically deleted in mature osteoblast and osteocytes, the mice developed severe low bone mass due to reduced bone formation and increased matrix resorption [ 106].
These mice develop T-ALL at low to intermediate levels of penetrance.
