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These mice develop robust cytoplasmic inclusions containing huntingtin [ 50].
This is dependent on commensal microbes because germ-free MyD88 knockout mice develop robust diabetes.
Tg-SwDI mice develop robust accumulation of both vascular and parenchymal Aβ deposits with predominance of Aβ1-40 over Aβ1-42 in the perivascular/vascular areas starting at 3 to 5 months of age (Fig. S7A D).
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One out of 9 (11%) control mice developed robust brain metastasis whereas 8/17 (47%) mice in the DKK1 knockdown groups showed metastasis.
The mice developed robust titers against Aβ and the sera isolated from these mice stained mature, but not diffuse plaques in TgCRND8 mice.
Nf1 heterozygous (Nf1+/-) mice develop a robust neointima that mimics human disease.
In one important example, mice that express an N-terminal fragment of mutant htt terminating at the C-terminus of exon 2 (termed the Shortstop mouse) were reported to develop robust inclusion pathology without developing phenotypic abnormalities seen in the R6/2 or N171-82Q mofels of HD, which are also based on expression of mutant N-terminal htt fragments.
Recipient mice treated with the echinocandins received the same exposure to infected mice as did the non-echinocandin treated mice who developed robust infections.
Although natural hosts, such as Peromyscus leucopus, do not develop robust antitick immunity, inbred strains of mice and guinea pigs become immune to the salivary antigens secreted by feeding ticks (10, 26, 27 ).
Silver et al did not get robust DTH without PTX although in our hands mice immunized with MOG161 180 peptide and CFA (without PTX) did develop robust DTH.
What will happen if we fail to develop robust systems for accountability at local level?
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