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Under hypoxic conditions (four weeks at 10% O2) mice develop typical symptoms of PH, characterized by an increased muscularization of arterial blood vessels in the lung.
When injected with type II collagen (CII), the PyV MT mice develop typical signs of RA.
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All mice developed typical seizure behaviors of grade 3 or higher.
We show here that LTβR deficient mice did not develop ECM and survived more than 20 days, while C57BL/6J wild type mice developed typical neurological signs of CM, including postural disorders, ataxia, impaired reflexes and loss of grip strength, progressive paralysis and coma, and succumbed within a week after infection with 5 10% of parasitized erythrocytes (Figure 1A).
Although most of the mouse models develop typical amyloid plaques and cognitive deficits with age, the pathophysiology in young transgenic mice, reflecting preclinical forms of AD, is less well understood [ 63].
Traditional animal models, such as mice, rats, rabbits or pigs do not develop typical renal disease when given either Stx or E. coli 0157 H7 [ 14].
While behavioral testing of MPTP mice was considered to substantiate dopaminergic neurodegeneration, those were not performed as rodents do not develop typical parkinsonism and behavioral testing in MPTP mice has not proven to be consistently reliable [77], [78].
However, many laboratory animals do not develop typical listeriosis through the oral ingestion of L. monocytogenes, such as mouse, rat, rabbit and guinea pig.
Most importantly, the surviving double knockout (FancD2−/−Aldh2−/−) mice developed a typical FA phenotype with various malformations, progressive bone marrow failure, and death due to leukemia.
As expected, the MCD-fed mice developed a typical feature of NASH: increased liver injury (Supplementary Figure S6A).
At a dose of 10 mg/kg bodyweight, mice developed a typical early-phase acute lung injury, characterized by lung edema, neutrophil influx, hypoxemia and reduced lung compliance.
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