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OPG-deficient mice develop early arterial calcification (31, 32).
Cngb3−/− mice develop early onset, slow progression of cone degeneration (30).
There was a room when mice develop early or medial stage of atherosclerosis, but they were not studied.
7) CD4-cre TGF-bRII f/f mice develop early aggressive autoimmunity and activated T cells appear to emerge over time.
Is there a defect not just in Tfh formation but also in their migration to interact with B cells? 7) CD4-cre TGF-bRIIf/f mice develop early aggressive autoimmunity and activated T cells appear to emerge over time.
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K-RasLA2 mice develop early-onset lung adenocarcinomas [22].
It has been reported previously that C57BL mice develop early-onset osteoarthritis when fed a high-fat diet [ 26].
Despite the low expression levels of mutant APP, Tg-SwDI mice develop early-onset robust accumulation of Aβ in the brain.
In contrast to Irs-1-/ mice, Irs-2-deficient mice develop early-onset diabetes due to a combination of peripheral insulin resistance and a loss of β-cell function [ 13, 15].
When R26PR is mated to either of two Cre lines, Mx1-cre or MMTV-cre, mice develop early-onset T-cell acute lymphoblastic leukemia (T-ALL) with median overall survival of 41 and 64 days for R26PR Mx1-cre and R26PR Mx1-cree, respectively.
Liu et al. demonstrated the essential role of miR-133a in the cardiomyocyte proliferation: miR-133a-1 miR-133a-1 miR-133a-1-mutand miR-133a-2 miR-133a-2 miR-133a-2l defects that led to perinatal death, whereas mice that survivedevelopedthood succumbearly DCM and heart failarge
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