Sentence examples for methylation in adjacent from inspiring English sources

Colorectal tumors averaged 54.9% methylation (SEM = 1.1%) versus 64.3% (SEM = 0.5%) methylation in adjacent normal tissue, corresponding to an average relative demethylation of 14.6% (P<0.001).

Interestingly, GSTP1 methylation in adjacent nonneoplastic tissues also correlated with clinical outcome [ 28].

*Where the range of methylation in adjacent (Adj) normal tissue is high across multiple studies, this range is indicated in parentheses before the number analyzed.

Furthermore, they found RASSF1A methylation in adjacent non-tumor tissues, suggesting that this epigenetic change is potentially an early and critical event in childhood neoplasia.

DNA methylation in adjacent histologically normal liver tissue of hepatocellular carcinoma has been reported from several groups and is now accepted as an early event in cancer development [ 8].

Here, using a sensitive MS-PCR method, we found 70% of carcinoma tissues from a Central European population to display GSTP1 hypermethylation with rare methylation in adjacent normal tissues, supporting its value as a marker.

The expression of other noncoding RNA genes is also known to be regulated by changing the methylation status in adjacent chromosome regions.

An interpretation of RF binding at pattern 3 DMRs with respect to CpG-density is that RF binding occurs in regions of elevated CpG-density, with coordinated methylation changes in adjacent lower CpG-density regions.

No differences in LINE-1 methylation were found by age or gender, but a significant difference was found for side, with lower levels of methylation in normal adjacent right colon (63.0%) compared to left colon (65.5%, P = 0.016) and stage, with lower levels of methylation for tumors in stages 3 and 4 (51.9%) compared to stages 0 to 2 (57.1%, P = 0.028).

Aberrant methylation in tissue adjacent to breast tumor has already been reported previously for RASSF1A [ 20, 21] and HIN-1 [ 21].

We chose a diverse set of genes and two DNA repeats (Table  1) to assay for DNA methylation in cancer, adjacent and control mammoplasty tissues.