Sentence examples for methylation in multiple from inspiring English sources

A subset of colorectal cancers exhibit promoter methylation in multiple genes, referred to as the CpG island methylator phenotype (CIMP) [ 14, 16].

Differentially methylated regions (DMRs) are genomic regions showing different degrees of DNA methylation in multiple samples.

A subset of colorectal cancers exhibit promoter methylation in multiple genes; these tumors are referred to as the CpG island methylator phenotype (CIMP) (Toyota et al. 1999).

Lodygin D, Tarasov V, Epanchintsev A, Berking C, Knyazeva T, Korner H, et al. Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer.

It provides a simple and rapid method for detecting DNA methylation, it has high sensitivity to simultaneously detect methylation in multiple target genes, the reaction endpoint is visually detectable, and DNA methylation can be measured with the corresponding standard curve.

Thus, through functional epigenetics, we identified OPCML as a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies.

A total of 58 out of 109 glioblastomas showed average methylation >non-neoplastic brain in at least one clinical sample; 86% had homogeneous methylation status in multiple samples.

Through the introduction of next-generation sequencing technologies (NGS) simultaneous analysis of methylation motifs in multiple regions provides the opportunity for hypothesis-free study of the entire methylome.

By investigating a series of clonally expanded 5-Aza-dC-recovered cells, we found substantial gene expression as a result of incomplete DNA methylation recovery in multiple 5-Aza-dC-recovered clones.

It will facilitate genome-wide DNA methylation studies in multiple and complex clinical samples.

Histologically normal breast tissues adjacent to breast tumors frequently exhibit methylation changes in multiple genes.