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For detection of methylated, cancer-derived, DNA in feces it is preferable that there is minimal methylation in surrounding non-neoplastic colon tissue.
Similarly, if more than 75% of the tumor samples lied below the 25% of methylation in surrounding samples, this CpG site was considered as frequently hypomethylated in tumors (Figure S3).
Although the difference did not reach statistical significance, the frequency of ADRA1B promoter methylation in surrounding epithelial tissues with IM was higher than that in surrounding epithelial tissues without IM.
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Their methylation status in surrounding normal breast tissues has not been examined thoroughly although this may well be important for a better understanding of breast carcinogenesis.
However, the precise 50% methylation (within 0.1% error) of Region III despite full methylation or unmethylation of CpGs in surrounding regions, and the activation of the maternal allele of IGF2 concurrent with the loss of methylation of Region III in 5-azacytidine treated neonatal fibroblasts, strongly suggest that Region III comprises an allele-specific DMR essential to PSGE of IGF2 in opossums.
When we analysed the correlations between ADRA1B promoter methylation and the presence of IM in surrounding epithelial tissues, ADRA1B promoter methylation was detected in 12 of 26 (46.2%) gastric epithelial tissues with IM and in two of eight (25.0%) gastric epithelial tissues without IM.
In gastric cancer, ADRA1B promoter methylation occurs frequently in both cancer tissue as well as in surrounding epithelial tissue.
Our data demonstrates tumour-specific promoter methylation is found in a significant proportion of cases at P16, CYGB and CYCA1, while methylation of the promoters of ECAD and RARβ was also seen in surrounding normal tissues.
In surrounding states, the situation had improved.
THE FLOOR PLAN Factor in surrounding apartments.
Views take in surrounding treetops and mountains.
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