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We initially assessed tumor metabolic response using FDG uptake without knowledge of any other parameters.
With the advent of global profiling capabilities, it is now possible to study metabolic response using a systems biology approach.
This same group of investigators validated the previous findings using this definition of metabolic response, using 65 patients.
The early metabolic response using FDG PET/CT could have a predictive value for the assessment of histopathologic non-response of stage II/III breast cancer treated with neoadjuvant chemotherapy.
Tumour metabolic response using fluorodeoxyglucose (FDG -positron emission tomography (PET) has been studied in advanced ovarian cancer and the FDG -positronremissionuggestomographyre is PETential to improve early detection of response (Fig. 1).
In the present study, we found that the early metabolic response using serial FDG PET/CT had a high predictive value for the histopathologic non-response of stage II/III breast cancer treated with neoadjuvant chemotherapy.
Similar(53)
We subjected both cell types to phsyiologically inspired environmental in vitro perturbations and measured their metabolic responses using mass spectrometry.
TTP and OS were then compared according to metabolic response categories using the log-rank test.
We sought to isolate the origin of age-related BOLD changes by comparing blood-flow and oxygen-metabolic constituents of the BOLD response using dual-echo arterial spin labeling during visual stimulation and CO2 ingestion.
Insights obtained from transcriptional and metabolic responses were used to determine metabolic engineering sites.
Three different classes of estrogen hormone therapy were monitored in comparison to controls for their effect on the short-term metabolic response of tumors using both FDG and [11C]-MET PET scans.
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