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To compare the bioavailability of dK with phylloquinone, we conducted a metabolic study using a crossover design.
A metabolic study using nuclear megnetic resonance (NMR) spectroscopic analysis in glioblastoma cells cultured with isotope-labeled glucose and glutamine demonstrated that glutamine supplied the majority of aneplerotic carbon for the TCA cycle in cancer cells [35].
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Further metabolic studies using microdialysis in the horse are encouraged.
The lead structure was also examined in the preliminary metabolic stability study using human liver microsomes (HMLs).
This first exploratory study shows that subtle metabolic changes resulting from an anti-inflammatory treatment could only be determined using a metabolic perturbation test in a well-designed clinical study using metabolic profiling analysis.
We performed in silico metabolic engineering studies using a genome-scale reconstruction of C. ljungdahlii metabolism and the OptKnock computational framework to identify gene knockouts that were predicted to enhance the synthesis of these native products and non-native products, introduced through insertion of the necessary heterologous pathways.
Metabolic stability studies using pooled human liver microsomes indicate a range of stabilities.
The BP studies were conducted separately from the metabolic cage studies, using different mice, in order to minimize handling of animals during hemodynamic recordings.
Third, to conclusively assay the glycolytic capacity of the S2 cell cultures, metabolic flux studies using the Seahorse XF24 multiparameter analyzer was performed using glucose and 2dG as a specific inhibitor of glycolysis with real-time measurement of the pH of the extracellular media.
Another study using a metabolic network as a representation of the individuals also concluded that epistasis plays a fundamental role in heterosis [ 58].
The NHANES study, using an arbitrary metabolic syndrome definition, showed that being overweight with metabolic syndrome was associated with higher CRP than being overweight without the syndrome (21).
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