Sentence examples for membrane localization has from inspiring English sources

In animal systems, the βγ dimer is anchored to the plasma membrane by a prenyl group present in the γ subunit and membrane localization has proven vital for heterotrimer function.

Endoplasmic reticulum membrane localization has been suggested [79].

Endoplasmic reticulum membrane localization has been confirmed for the enzyme [60].

This membrane localization has recently generated interest in the use of nucleolin as a tumor marker and therapeutic target.

33, 36 Although PDK1 membrane localization has been largely investigated and the affinity of the PDK1-PH domain for the PI3K products suggested a potential PI3K-dependent PDK1 membrane translocation, this localization is still controversial.

This also suggests that the carboxy terminal hyper-variable domain of these proteins, which functions to target membrane localization, has little importance in the conformation of the active form.

Attributes such as membrane localization have been suggested to influence performance of a protein in a two-hybrid screen.

In order to understand the molecular basis of NIS inability to target the plasma membrane in a large fraction of BC, genes whose expression is associated to NIS plasma membrane localization have been recently identified by microarray analysis [ 34].

Since cytosolic HSPs do not contain the leader peptides enabling membrane localization, it has been speculated that other proteins possessing transmembrane domain shuttle HSPs from the cytosol to the plasma membrane or that HSPs directly interact with lipid components of plasma membrane.

The cell membrane is such a structure due to its high lateral elastic modulus, and is actually endowed with MS channels, although the correlation between the highly stressed membrane region and the MS channel localization has yet to be demonstrated.

In contrast, those drug targets with a cell membrane or extracellular localization had a relatively lower protein and DNA sequence identity (one-sided Wilcoxon rank-sum test, P < 0.05).