Sentence examples for membrane localization is from inspiring English sources
Subcellular localization analysis showed that AtGILP is localized in the plasma membrane and its plasma membrane localization is dependent on its LITAF domain.
Finally, we must consider that nuclear membrane localization is NLS-independent.
However, many of the prerequisites to AKT phosphorylation have not been fully clarified, i.e., whether PtdInsP3 binding or membrane localization is indispensable for AKT phosphorylation by PDK1.
We hypothesized that PtdInsP3 binding and membrane localization is not required for AKT phosphorylation and activation by PDK1 if the two proteins could be brought into proximity as stable complex with proper conformation by alternative mechanisms.
Membrane localization is not a general requirement for all src-family kinases, as a related kinase Frk, which also lacks a native myristylation sequence, failed to enhance soft agar colony growth when targeted to the membrane (unpublished data).
Interestingly, expression of non-myristoylated CK1ε was unable to promote either anchorage-independent growth or tumor formation in vivo (Fig. 6A), consistent with the possibility that membrane localization is required to induce activation of CK1ε, in a manner similar to other ectopically expressed signaling molecules, such as AKT, RAF or PI3-kinase [29], [30], [31] (Fig. 6A).
3) The protein localization data are unclear, because the conclusions regarding membrane localization are compromised by the apparent membrane ruffling that causes a higher local density of membrane that can give the false appearance of concentration.
A crystal structure (2HQW; 1.96 Å) of calcium-saturated CaM bound to NR1C1 (peptide spanning 875 898) showed that NR1 S890, whose phosphorylation regulates membrane localization, was solvent protected, whereas the endoplasmic reticulum retention motif was solvent exposed.
Ae2 membrane localization was lost between 4 and 8 hours after initiation of meiotic progression (Figure 8A,C), the same period during which HCO3−/Cl− exchange becomes inactivated [11].
Although minor changes in TGR5 expression and plasma membrane localization were noted for several mutations, the premature stop codon Q296X was the only mutation with a major impact.
Location of the signal sequence responsible for the outer membrane localization was determined using the SignalP 3.0 server [115] (http://www.cbs.dtu.dk/services/SignalP/) with default parameters for Gram-negative bacteria.
